Table 3.
Odds ratios and 95% confidence intervals for methionine levels (sex-specific quintiles) and risk of pancreatic cancer by years of follow-up before cancer diagnosis
| Methionine (μmol/L) | All | <=4 years | >4 years | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Controls | Cases | OR 95% CI | Controls | Cases | OR 95% CI | Controls | Cases | OR 95% CI | |
| q1 | 92 | 106 | 1.0 | 31 | 49 | 1.0 | 61 | 57 | 1.0 |
| q2 | 92 | 75 | 0.8 (0.5–1.3) | 31 | 36 | 0.6 (0.3–1.4) | 61 | 39 | 1.0 (0.5–1.8) |
| q3 | 93 | 84 | 0.8 (0.5–1.3) | 36 | 20 | 0.3 (0.1–0.7) | 57 | 64 | 1.3 (0.7–2.3) |
| q4 | 92 | 93 | 1.0 (0.6–1.7) | 33 | 29 | 0.5 (0.2–1.1) | 59 | 64 | 1.4 (0.8–2.6) |
| q5 | 92 | 103 | 1.0 (0.6–1.6) | 40 | 39 | 0.4 (0.2–1.0) | 52 | 64 | 1.5 (0.9–2.8) |
| every quintile | 1.0 (0.9–1.1) | 0.8 (0.7–1.0) | 1.1 (1.0–1.3) | ||||||
| p for heterogeneity | 0.02 | ||||||||
| Men | |||||||||
| <=21.01 | 44 | 36 | 1.0 | 14 | 18 | 1.0 | 30 | 18 | 1.0 |
| 21.01–24.39 | 44 | 46 | 2.3 (1.1–4.9) | 16 | 20 | 1.4 (0.4–4.4) | 28 | 26 | 4.1 (1.4–12.0) |
| 24.39–27.87 | 45 | 44 | 1.8 (0.9–3.8) | 17 | 12 | 0.7 (0.2–2.5) | 28 | 32 | 3.9 (1.4–10.8) |
| 27.87–31.50 | 44 | 38 | 2.2 (1.0–4.8) | 18 | 11 | 0.6 (0.2–2.5) | 26 | 27 | 5.1 (1.6–16.1) |
| >31.50 | 44 | 57 | 2.5 (1.2–5.4) | 21 | 27 | 1.2 (0.4–3.9) | 23 | 30 | 4.9 (1.6–14.8) |
| every quintile | 1.2 (1.0–1.4) | 1.0 (0.8–1.3) | 1.4 (1.1–1.7) | ||||||
| p for heterogeneity | 0.05 | ||||||||
| Women | |||||||||
| <=20.37 | 48 | 70 | 1.0 | 17 | 31 | 1.0 | 31 | 39 | 1.00 |
| 20.37–22.42 | 48 | 29 | 0.3 (0.2–0.7) | 15 | 16 | 0.2 (0.03–1.2) | 33 | 13 | 0.3 (0.1–0.8) |
| 22.42–25.23 | 48 | 40 | 0.4 (0.2–0.8) | 19 | 8 | 0.1 (0.02–0.7) | 29 | 32 | 0.6 (0.2–1.4) |
| 25.23–28.62 | 48 | 55 | 0.6 (0.3–1.1) | 15 | 18 | 0.3 (0.06–1.5) | 33 | 37 | 0.7 (0.3–1.7) |
| >28.62 | 48 | 46 | 0.5 (0.3–1.0) | 19 | 12 | 0.1 (0.01–0.5) | 29 | 34 | 0.8 (0.4–1.8) |
| every quintile | 0.9 (0.8–1.0) | 0.7 (0.5–0.9) | 1.0 (0.8–1.2) | ||||||
| p for heterogeneity | 0.3 | ||||||||
| p for heterogeneity by sex | <0.01 | 0.1 | <0.01 | ||||||
The OR were estimated from conditional logistic regression based on matching factors and further adjustments for education, smoking status, cotinine concentration in plasma, baseline alcohol drinking, BMI and self-reported diabetes status at baseline.