TABLE 1.

E2072 plasma pharmacokinetic parameters in rats^a

	Cmax	Tmax	AUClast	AUCinf	Clb	Vdb	t½	%F
	ng/ml	h	ng · h/ml		l/h/kg		h
0.1 mg/kg i.v.			1800 ± 927	1969 ± 1071	0.06 ± 0.03	0.20 ± 79	2.30 ± 0.23
0.1 mg/kg p.o.	62.6 ± 43.0	0.83 ± 0.77	268 ± 267	605 ± 939	0.51 ± 0.40	2.98 ± 1.45	9.33 ± 14.9	17.4 ± 17.3
1 mg/kg i.v.			12,675 ± 7417	12,989 ± 7511	0.05 ± 0.03	0.21 ± 0.11	3.25 ± 1.13
1 mg/kg p.o.	1095 ± 1058	0.58 ± 0.44	2608 ± 818	3209 ± 776	0.33 ± 0.09	1.65 ± 0.69	3.72 ± 2.25	23.7 ± 6.6
10 mg/kg i.v.			90,150 ± 88,864	90,622 ± 9043	0.27 ± 0.12	1.43 ± 0.82	3.55 ± 0.61
10 mg/kg p.o.	7097 ± 5549	1.03 ± 0.57	33,448 ± 9737	33,762 ± 9867	0.32 ± 0.09	1.44 ± 0.46	3.17 ± 0.60	37.3 ± 10.9
30 mg/kg i.v.			202,098 ± 86,045	204,159 ± 86,969	0.18 ± 0.08	1.08 ± 0.78	4.07 ± 0.98
30 mg/kg p.o.	13,017 ± 6148	1.43 ± 0.35	76,062 ± 26,257	76,570 ± 26,341	0.51 ± 0.40	2.39 ± 2.18	3.15 ± 0.46	37.5 ± 12.9

^a Data are presented as mean ± S.D.; n = 4–9 rats per dose group.

^b For intravenous data, Cl and V_d are presented. For oral data, apparent clearance (Cl/F) and apparent volume (V_d/F) are presented.