TABLE 3.

Plasma pharmacokinetic parameters in rats after intravenous administration of E2072 and E2072-homodisulfide^a

Dose	Cmax	Tmax	AUClast	AUCinf	Cl	Vd	t½,β
	ng/ml	h	ng · h/ml		l/h/kg	l/kg	h
E2072 (10 mg/kg)
E2072	57,226 ± 12,077	0.11 ± 0.08	86,652 ± 22,279	86,973 ± 222,349	0.12 ± 0.26	19.0 ± 9.9	105 ± 40
E2072-homodisulfide	3134 ± 838	0.48 ± 0.48	120,303 ± 30,237	253,322 ± 108,052	–	–	208 ± 81
E2072-homodisulfide (5 mg/kg)
E2072	242 ± 173	3.33 ± 1.03	9149 ± 4386	12,177 ± 5214	–	–	102 ± 27
E2072-homodisulfide	103,952 ± 24,100	0.11 ± 0.08	2,492,590 ± 480,442	3,537,275 ± 1,052,897	0.0015 ± 0.0005	209 ± 52	101 ± 35

^a Data are presented as mean ± S.D.; n = 5–6 rats per dose group.