TABLE 4.

E2072 and E2072-homodisulfide plasma pharmacokinetic parameters in monkeys after intravenous and oral administration of 5 mg/kg E2072^a

	Cmax	Tmax	AUCinf	Clb	Vdb	t½,β	%F
	ng/ml	h	ng · h/ml	l/h/kg	l/kg	h
E2072
i.v.	68,013.3 ± 2698.4	0.08 ± 0.00	63,622.1 ± 7821.8	0.022 ± 0.003	0.72 ± 0.06	23.0 ± 1.2
p.o.	10,454.3 ± 1032.2	0.42 ± 0.14	24,935.6 ± 740.7	0.057 ± 0.003	0.79 ± 0.31	9.57 ± 3.43	39.1%
E2072-homodisulfide
i.v.	3272.8 ± 964.8	3.33 ± 1.15	105,771.6 ± 39,413.9	–	–	21.0 ± 0.95
p.o.	133.6 ± 14.6	5.33 ± 2.31	25,270.8 ± 6198.1	–	–	20.0 ± 1.85

^a Data are presented as mean ± S.D.; n = 3 monkeys per dose group.

^b For intravenous data, Cl and V_d are presented. For oral data, apparent clearance (Cl/F) and apparent volume (V_d/F) are presented.