Fig. 9.

Chromatograms and MSⁿ spectra of maraviroc glucuronides. A, multiple reaction monitoring chromatogram of maraviroc glucuronides with transitions at m/z 706 → 581 (M11) and at m/z 706 → 389 (M12) from metabolism reactions using human liver microsomes. B, MS³ spectra of M11 monitoring first/second precursor ions at m/z 706/581. C, MS² spectra of M12 monitoring precursor ion at m/z 706. The proposed structures of fragmented ions are shown near the corresponding peaks. D, multiple reaction monitoring chromatogram of maraviroc glucuronides with transition at m/z 706 → 581 (M11) and at m/z 706 → 389 (M12) in urine collected at 0 to 2 h from the volunteer.