TABLE 1.

Comparison of metabolic ratios of CYP3A5 and its mutants with those of CYP3A4

The enzymes indicated were transiently expressed in COS-7 cells. Metabolism experiments for maraviroc were performed, and oxidative metabolites M1, M2, and M3 were measured as described under Materials and Methods. Metabolic ratios (M1/M2 and M1/M3) are presented as means ± S.D.

Name	M1/M2	M1/M3
CYP3A5	24.4 ± 1.3	30.4 ± 4.2
L57F	11.8 ± 1.2	13.6 ± 1.4
S107P	24.1 ± 2.7	10.9 ± 4.0
L108F	1.29 ± 0.05	1.7 ± 0.03
F146V	20.0 ± 2.9	25.6 ± 4.0
G186S	25.4 ± 1.5	38.9 ± 3.2
S206N	34.0 ± 2.1	47.6 ± 3.6
G214D	6.14 ± 0.2	4.6 ± 0.03
L219F	17.9 ± 0.4	16.7 ± 0.1
S239C	27.3 ± 4.0	42.3 ± 3.9
L240V	13.3 ± 6.3	14.9 ± 4.9
V369I	18.2 ± 4.5	25.1 ± 2.8
I371M	20.3 ± 2.8	15.0 ± 1.5
S392V	22.5 ± 0.1	18.8 ± 2.3
T478L	25.6 ± 2.7	38.1 ± 2.7
Q479G	25.6 ± 2.2	23.4 ± 1.1
CYP3A4	1.5 ± 0.5	1.6 ± 0.8