Fig. 5.

The analgesic activity of compound D in formalin test. Vehicle and different doses of the compound D were administered 30 min prior to subplantar injection of formalin and the time spent for licking was measured during a 0-5 min (acute phase) and 20-30 min (chronic phase) period starting after formalin injection. Morphine (10 mg/kg, i.p.) was used as reference drug. Data are mean ± SEM of 6 animals in each group. *** P < 0.001 significantly different from control group (ANOVA with Scheffe post hoc test).