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. Author manuscript; available in PMC: 2012 Nov 18.
Published in final edited form as: Addict Biol. 2011 Mar 11;17(2):248–258. doi: 10.1111/j.1369-1600.2010.00311.x

Figure 1.

Figure 1

Figure 1

Figure 1

Rapamycin pretreatment during conditioning does not affect the acquisition of a cocaine-induced place preference or locomotor sensitization. (a) Schematic of experimental design. Mice received IP DMSO vehicle (n=12) or 10 mg/kg rapamycin (n=12) 1 hr prior to each cocaine/saline pairing, followed by a drug-free posttest (#1), a rapamycin-pretreated posttest (#2), a 21-day withdrawal period, and a test for the expression of cocaine-induced locomotor sensitization, following 1-hr rapamycin or vehicle pretreatment. (b) Rapamycin pretreatment during place-conditioning procedures had no effect on locomotor activity elicited by cocaine or by saline. (c) Rapamycin pretreatment during place-conditioning procedures also did not block a conditioned place-preference when animals were tested 24 hrs later in a drug-free state. Data are expressed as means ± SEM (error bars). *p<0.05 vs. saline-paired compartment (i.e., place-preference).