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. Author manuscript; available in PMC: 2012 Nov 18.

Published in final edited form as: Addict Biol. 2011 Mar 11;17(2):248–258. doi: 10.1111/j.1369-1600.2010.00311.x

Rapamycin pretreatment attenuates cocaine-induced place preference and blocks long-term locomotor sensitization. (a) Compared to vehicle-pretreated animals (n=10), 10 mg/kg rapamycin pretreatment (n=11) 1 hr prior to a post-conditioning test attenuated the expression of a cocaine-induced place-preference. (b) Compared to vehicle-pretreated animals (n=11) rapamycin pretreatment (n=12) 1 hr prior to a 15 mg/kg cocaine challenge injection conducted at 3 weeks withdrawal blocked sensitization of the locomotor-activating effects of cocaine. Data are expressed as means ± SEMs. *p<0.05 vs. Vehicle; +p<0.05 vs. acute cocaine (sensitization).

Rapamycin pretreatment attenuates cocaine-induced place preference and blocks long-term locomotor sensitization. (a) Compared to vehicle-pretreated animals (n=10), 10 mg/kg rapamycin pretreatment (n=11) 1 hr prior to a post-conditioning test attenuated the expression of a cocaine-induced place-preference. (b) Compared to vehicle-pretreated animals (n=11) rapamycin pretreatment (n=12) 1 hr prior to a 15 mg/kg cocaine challenge injection conducted at 3 weeks withdrawal blocked sensitization of the locomotor-activating effects of cocaine. Data are expressed as means ± SEMs. *p<0.05 vs. Vehicle; +p<0.05 vs. acute cocaine (sensitization).