Table 3.
Morbidity Before (Group 1) and After (Group 2) Permissive Hypercapnia
| Morbidity | Group 1 (n = 42) | Group 2 (n = 49) | p Value |
|---|---|---|---|
| Morbidity (overall), % | 83.3 | 65.3 | 0.052 |
| Neurologic, % | 45.2 | 26.5 | 0.06 |
| Cardiac, % | 2.4 | 2.0 | 1.0 |
| Repeat tube thoracostomy, % | 35.7 | 10.2 | 0.003* |
| O2 requirement at discharge, % | 21.4 | 22.4 | 0.94 |
| Persistent pulmonary disease, % | 14.3 | 10.2 | 0.56 |
| Recurrent CDH, % | 4.76 | 6.1 | 1.0 |
| Gastrointestinal (all), % | 19.1 | 20.4 | 0.87 |
| Nissen, % | 9.5 | 4.1 | 0.41 |
| Gastrostomy, % | 16.7 | 12.2 | 0.54 |
| Nissen + Gastrostomy, % | 9.5 | 4.1 | 0.41 |
| Hematologic, % | 19.1 | 6.1 | 0.10 |
| Infection, % | 14.3 | 20.4 | 0.44 |
| Renal, % | 7.1 | 0 | 0.09 |
| ECMO, % | 61.9 | 28.6 | 0.001* |
| Days on ECMO, mean ± SEM | 15.2 ± 1.6 | 13.2 ± 2.7 | 0.49 |
| iNO†, n (%) | 12/37 (32.4) | 27/46 (58.7) | 0.02* |
| HFOV†, n (%) | 26/37 (70.2) | 34/45 (75.6) | 0.59 |
| Timing of repair, d, mean ± SEM | 5.9 ± 1.01 | 9 ± 0.93 | 0.03* |
| Days intubated after repair, mean ± SEM | 25 ± 3.9 | 19.9 ± 9.1 | 0.61 |
| Days intubated after repair (modified), mean ± SEM | 26 ± 3.9 | 11 ± 1.5 | 0.002* |
| Hospital stay, d, mean ± SEM | 50.9 ± 7.9 | 42.2 ± 9.2 | 0.48 |
*
Denotes statistical significance, p < 0.05.
†
Variation in group size secondary to unobtainable chart data.
CDH, congenital diaphragmatic hernia; ECMO, extracorporeal membrane oxygenation; HFOV, high frequency oscillatory ventilation; iNO, inhaled nitric oxide.