Table 1.
Clinical and pathologic features of 1038 men in the SEARCH database with available prostate-specific antigen nadir data, sorted by body mass index
| Features | Normal weight <25 kg/m2 | Overweight 25.0–29.9 kg/m2 | Obese ≥30 kg/m2 | p* |
|---|---|---|---|---|
| No. of patients (%) | 228 (22) | 473 (46) | 337 (32) | |
|
| ||||
| Year of surgery, median (IQR) | 2005 (2003–2007) | 2005 (2003–2007) | 2006 (2004–2007) | 0.0185† |
|
| ||||
| Follow-up, mo, median (IQR) | 44.1(19.5–69.9) | 42.1(20.7–66.4) | 40.4(15.6–61.8) | 0.0071† |
|
| ||||
| Age, yr, mean ± SD | 61.1 ± 6.0 | 60.9 ± 6.0 | 59.5 ± 5.9 | 0.0008‡ |
|
| ||||
| Race (%) | 0.293 | |||
| White | 103 (45) | 235 (50) | 156 (46) | |
| Black | 113 (50) | 208 (44) | 168 (50) | |
| Other | 12 (5) | 30 (6) | 13 (4) | |
|
| ||||
| PSA, ng/ml, median (IQR) | 6.7 (5.0–10.0) | 5.9 (4.5–8.4) | 5.8 (4.5–8.6) | 0.0219† |
|
| ||||
| Pathologic Gleason sum (%) | 0.077 | |||
| 2–6 | 80 (35) | 181 (38) | 97 (29) | |
| 3 + 4 | 102 (45) | 193 (41) | 165 (49) | |
| ≥4 + 3 | 46 (20) | 99 (21) | 75 (22) | |
|
| ||||
| Prostate weight, g, median (IQR) | 37.8 (30.0–48.3) | 40.0 (32.1–51.4) | 43.0 (33.4–55.0) | 0.0003† |
|
| ||||
| Positive surgical margin (%) | 101 (44) | 213 (45) | 158 (47) | 0.8048 |
|
| ||||
| Capsular penetration (%) | 36 (16) | 83 (18) | 56 (17) | 0.8352 |
|
| ||||
| Seminal vesicle invasion (%) | 10 (4) | 42 (9) | 25 (7) | 0.104 |
|
| ||||
| Lymph node involvement (%) | 1 (0.4) | 7 (1.5) | 10 (3.0) | 0.208 |
|
| ||||
| PSA nadir, ng/ml | 0.055 | |||
| 0 (undetectable) | 140 (61) | 269 (57) | 182 (54) | |
| 0.01–0.09 | 72 (32) | 156 (33) | 108 (32) | |
| 0.1–0.19 | 10 (4) | 19 (4) | 14 (4) | |
| ≥0.2 | 6 (3) | 29 (6) | 33 (10) | |
IQR = interquartile range; SD = standard deviation; PSA = prostate-specific antigen.
*
p value by chi square, except where noted.
†
p value by Kruskal-Wallis.
‡
p value by analysis of variance.