Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Trends Genet. 2012 Aug 30;28(12):624–631. doi: 10.1016/j.tig.2012.08.003

Figure 1.

Figure 1

Structural organization of human RecQ helicases. All the RecQ helicase members possess a highly conserved helicase domain (yellow). The nuclear localization signal (purple) is present at the C-terminus in most of the family members, except in RECQL4 which has two nuclear targeting sequences (NTS1and NTS2) that are present at the N-terminus. The RQC (pink) and helicase and RNase C-terminal (HRDC) domain (black) are present at the C-terminus of helicase domain except for in RECQL4. The WRN protein is unique among human RecQ helicase members in having an exonuclease domain (green) at the N-terminus. The N-terminus of RECQL4 show sequence similarity with the Sld2 protein in yeast that is important for DNA replication and cell viability. A putative mitochondrial targeting sequence is present at the N-terminus of RECQL4 (light blue).