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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Trends Genet. 2012 Aug 30;28(12):624–631. doi: 10.1016/j.tig.2012.08.003

Figure 2.

Figure 2

RECQL4 has a narrower substrate range than other RecQ helicases. The RECQL4 helicase can unwind forked duplexes (A), D-loops (B), and bubble (C) structures but not duplex DNA (D), Holliday junctions (E), or G-quadruplex structures (F). However, the unwinding activity from the N-terminal domain can utilize duplex DNA substrates.