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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Trends Genet. 2012 Aug 30;28(12):624–631. doi: 10.1016/j.tig.2012.08.003

Figure 3.

Figure 3

Cellular localization and stress responses surrounding RECQL4. Under normal circumstances, RECQL4 can be found in the nucleoplasm and at telomeres, where it participates in DNA maintenance. Without stress, RECQL4 interacts with p53 and they shuttle between the nucleus and mitochondria. After stress, p53 and RECQL4 re-localize to the nucleus where p53 coordinates the DNA damage response including down-regulating RECQL4 expression. In both the nucleus and mitochondria, RECQL4 can localize to DNA damage and participate in modulating DNA maintenance processes.