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. Author manuscript; available in PMC: 2013 Sep 21.
Published in final edited form as: Immunity. 2012 Sep 6;37(3):451–462. doi: 10.1016/j.immuni.2012.05.030

Figure 1. Compound loss of Bim and other BH3-only proteins can cause organ-specific autoimmune disease.

Figure 1

A. H&E stained sections of tissues from lethally irradiated Rag1•/• mice reconstituted with hematopoietic precursors from WT or Vav-BCL-2tg mice, or mice lacking the indicated BH3-only proteins. Arrows indicate areas of lymphocytic infiltration. B. Immunofluorescent staining of Rag1•/• mouse tissues with serum from Rag1•/• mice reconstituted with hematopoietic precursors from WT or Vav-BCL-2tg mice, or mice lacking the indicated BH3-only proteins. Auto-antibody reactivity is shown in green and nuclear DAPI staining in blue. Images are representative of n=4 mice per group.