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. Author manuscript; available in PMC: 2013 Sep 21.
Published in final edited form as: Immunity. 2012 Sep 6;37(3):451–462. doi: 10.1016/j.immuni.2012.05.030

Figure 2. Spontaneous organ-specific autoimmunity in Bbc3•/•Bcl2l11•/• mice.

Figure 2

A. Graph of the cumulative clinical scores of 10 organs quantifying autoimmune infiltration and destruction in aged mice deficient in the proteins indicated. Groups were compared using an ANOVA with a multiple comparison Tukey’s post-test. * p<0.05, *** p<0.001. Mean ages at time of analysis were: Aire•/• d237 (n=11); Pmaip1•/• d147 (n=9); Bad•/• d165 (n=7); Bcl2l11•/• d141 (n=8); Bad•/•Bcl2l11•/• d166 (n=5); Pmaip1•/•Bcl2l11•/• d153 (n=13); Bbc3•/•Bcl2l11•/• d143 (n=15). B. Representative images of H&E stained sections of tissues taken from aged Bbc3•/•Bcl2l11•/• mice, with arrows indicating lymphocytic infiltration. C. Images of H&E stained sections of pancreas taken from Rag1•/• mice that had been injected with T-cells from WT or healthy Bbc3•/•Bcl2l11•/• mice, with arrows indicating lymphocytic infiltration and tissue destruction. D. Graph of the incidence and severity of pancreatitis in Rag1•/• mice that had been injected with T-cells from WT or Bbc3•/•Bcl2l11•/• mice (n=8). E. CD44 vs. CD62L expression on CD4+ splenic T-cells, with the mean proportion of activated CD44hiCD62Llo/− T-cells shown.