Fig 2.

Additional images from the intact cadaver of a patient with known GBM.

A, Axial 8-T GE MR image (matrix = 1024 × 1024;TR/TE = 600/12; flip angle = 20°) in the patient with known GBM involving the splenium of the corpus callosum. This is 2 mm superior to the image in Figure 1A. Numerous small vessels are visible in the tumor bed. A = anterior, P = posterior.

B and C, Hematoxylin-eosin-stained sections (original magnification ×200) to the foci depicted by the arrow in A (B) and the arrowhead in A (C). B, Histologic specimen shows larger vessels (arrow) in dense concentration. Vessels in this region of exophytic tumor are also severely deformed in A, with loss of normal organization. Vessels can be seen crossing from the corpus callosum into the tumor. C, Image shows tumor infiltration with vascular density similar to white matter.