Fig. 2.

NK cell activation via the “missing self” mechanism does not compromise CD8⁺ T cell response to MCMV. BALB/c mice were intravenously (i.v.) injected with 2 × 10⁵ plaque-forming units (PFU) of either WT or Δm04 MCMV. For in vivo depletion of CD8 T cells, mice were intraperitoneally (i.p.) injected with 300 μg of purified monoclonal antibody (mAb) to CD8 (YTS 169.4) on days 1 and 5 p.i. Control groups were treated with phosphate-buffered saline (PBS). On day 7 p.i., viral titers in indicated organs were determined by the plaque assay. Circles represent the titers of individual mice, and horizontal bars represent the median values. Dotted line, detection limit