Figure 7. The structure of the embedded Module III (ERα-XBP1-NFκB-OCT1-PAX2).

The subplots illustrate gene expression patterns and corresponding SNR values for those module components. Module III mainly contains four bi-span loops, self-inhibition loops (NFκB, OCT1 and XBP1) and one co-inhibitory loop (XBP1 and NFκB). And the corresponding time-course gene expression plots and inherent expression patterns are given in right panels, together with the up-/down-regulated information (+/−) for each gene node on the rightmost column of the bottom plot. XBP1 is up-regulated, and NFκB is down-regulated in Module III.