Table 1. Apparent diffusion coefficient values measured in normal liver at 1.5 T.
Reference | Mean ADC (10−3 mm2 s−1) | Standard deviation | Range | Number of subjects | b-values (s mm−2) | Comments |
Taouli et al [10] | 1.60 | 0.13 | 1.44–1.88 | 10 v | 0, 500 | Conventional |
1.52 | 0.15 | 1.28–180 | With parallel imaging | |||
1.51 | 0.21 | 1.27–1.99 | Diffusion tensor/parallel imaging | |||
Mürtz et al [11] | 0.92–0.96a | 0.09–0.14 | 0.62–1.20 | 12 v | 50, 300, 700, 1000, 1300 | Pulse triggered |
1.03–1.14 | 0.22–0.40 | 0.67–2.57 | Non-triggered | |||
Kim et al [12] | 1.05/1.02b | 0.30/0.25 | 6 v/126 p | 3, 57, 192, 408, 517, 850 | ||
1.55/1.16 | 0.37/0.42 | 3, 57, 192, 408, 192, 408 | ||||
4.8/3.55 | 2.37/1.75 | 3, 57 | ||||
Ichikawa et al [13] | 2.28 | 1.23 | 46 p | 1.6, 55 | ||
Taouli et al [14] | 1.83 | 0.36 | 1.4–2.55 | 66 p | 0, 500 | |
1.51 | 0.49 | 1.12–2.71 | 0, 134, 267, 400 | |||
Kwee et al [15] | 1.60/1.62/1.57c | 0.14/0.18/0.15 | 11 v | 0, 500 | Breath-hold | |
2.13/2.27/2.07 | 0.33/0.47/0.43 | Respiratory triggered | ||||
1.65/1.62/1.65 | 0.09/0.16/0.17 | Free breathing (7 mm slice) | ||||
1.64/1.66/1.57 | 0.13/0.11/0.19 | Free breathing (5 mm slice) | ||||
Yamada et al [16] | 0.87 | 0.26 | 78 p | 30, 300, 900,1100 | ADC | |
0.76 | 0.27 | Diffusion coefficient (DC) | ||||
Müller et al [17] | 1.39 | 0.16 | 10 v+9 p | 8 b-values; bmax 328–454 | ||
Namimato et al [18] | 0.69 | 0.31 | 51 p | 30, 1200 | ||
This study | 1.04 | 0.05 | 0.95–1.11 | 10 v | 100, 200, 500, 750, 1000 | Free breathing |
ADC, apparent diffusion coefficient; p, patients; v, volunteers.
In studies including patients, only ADC values relating to measurements performed in normal liver are quoted here.
aValue range for 3 directions.
bVolunteers/patients.
cEach sequence repeated three times.