Table 2. δ-tocotrienol-induced haematological alterations in irradiated mouse peripheral blood sampled at 3–28 days after total body irradiation.
| Parameter studied | Days after irradiation (7 Gy) |
|||||||||||
| Day 3 |
Day 7 |
Day 10 |
Day 14 |
Day 21 |
Day 28 |
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| Vehicle | DT3 | Vehicle | DT3 | Vehicle | DT3 | Vehicle | DT3 | Vehicle | DT3 | Vehicle | DT3 | |
| RBC (106 cells µl−1) | 8.95 (0.40) | 8.40a (0.52) | 7.61 (0.74) | 7.68 (0.42) | 7.20 (0.31) | 7.74b (0.34) | 7.32 (0.42) | 7.87a (0.97) | 8.63 (0.52) | 9.12 (0.42) | 8.37 (0.35) | 8.55 (0.31) |
| Haemoglobin (µg µl−1) | 13.36 (0.61) | 12.76a (0.54) | 12.19 (0.77) | 10.90 (3.63) | 11.23 (0.43) | 12.06b (0.51) | 8.02 (0.96) | 8.38 (0.80) | 13.96 (0.85) | 14.63 (0.57) | 13.33 (0.29) | 13.74 (0.46) |
| Reticulocytes (103 cells µl−1) | 2.86 (1.24) | 3.91 (2.06) | 5.60 (2.15) | 13.28c (5.12) | 26.20 (11.18) | 141.25c (72.76) | 132.44 (39.99) | 204.08 (118.52) | 436.51 (190.46) | 225.69b (38.92) | 191.54 (14.59) | 169.73 (22.80) |
| Platelets (103 cells µl−1) | 1209.50 (30.30) | 1413.50c (27.60) | 267.63 (16.39) | 237.00a (7.72) | 84.63 (10.73) | 546.50c (135.07) | 256.43 (48.51) | 598.88a (159.57) | 611.75 (54.05) | 962.25c (68.99) | 801.00 (49.25) | 1125.88c (28.21) |
| Total leukocytes (103 cells µl−1) | 0.21 (0.03) | 0.15a (0.01) | 0.28 (0.03) | 0.56c (0.07) | 0.20 (0.02) | 0.58c (0.12) | 0.65 (0.06) | 1.33 (0.38) | 1.26 (0.21) | 2.83b (0.50) | 1.40 (0.13) | 2.10b (0.19) |
| Neutrophils (103 cells µl−1) | 0.06 (0.01) | 0.05 (0.0) | 0.11 (0.01) | 0.32c (0.04) | 0.06 (0.01) | 0.29c (0.07) | 0.12 (0.02) | 0.55a (0.20) | 0.46 (0.11) | 1.6c (0.35) | 0.72 (0.09) | 0.93a (0.03) |
| Lymphocytes (103 cells µl−1) | 0.11 (0.02) | 0.06a (0.01) | 0.12 (0.02) | 0.17 (0.03) | 0.11 (0.02) | 0.19b (0.03) | 0.48 (0.03) | 0.60a (0.12) | 0.59 (0.08) | 0.91a (0.12) | 0.59 (0.07) | 1.07c (0.11) |
| Monocytes (103 cells µl−1) | 0.0 (0.0) | 0.0 (0.0) | 0.01 (0.0) | 0.03c (0.01) | 0.0 (0.0) | 0.04c (0.01) | 0.02 (0.0) | 0.08a (0.03) | 0.07 (0.01) | 0.13b (0.02) | 0.08 (0.01) | 0.12a (0.01) |
| Eosinophils (103 cells µl−1) | 0.04 (0.01) | 0.03 (0.01) | 0.03 (0.0) | 0.03 (0.0) | 0.02 (0.0) | 0.05c (0.01) | 0.02 (0.0) | 0.07a (0.02) | 0.08 (0.01) | 0.14c (0.01) | 0.07 (0.01) | 0.09 (0.07) |
| Basophils (103 cells µl−1) | 0.01 (0.0) | 0.01 (0.0) | 0.01 (0.0) | 0.01 (0.0) | 0.01 (0.01) | 0.02a (0.0) | 0.03 (0.01) | 0.04 (0.01) | 0.05 (0.0) | 0.05 (0.01) | 0.02 (0.01) | 0.07c (0.07) |
DT3, δ-tocotrienol; RBC, red blood cell.
Values are mean, standard error in parentheses; n=8 per group. Data analysed using Student’s t-test.
ap<0.05 compared with irradiated control.
bp<0.01 compared with irradiated control.
cp<0.001 compared with irradiated control.