Skip to main content
. Author manuscript; available in PMC: 2012 Nov 19.
Published in final edited form as: Adv Cancer Res. 2012;114:21–57. doi: 10.1016/B978-0-12-386503-8.00002-8

Fig. 7.

Fig. 7

Primary endothelial cells assemble into cord-like structures on extracellular matrix, a process that requires EphB/EphrinB interaction. (A) Time-dependent assembly of primary endothelial cells on Matrigel. Note the appearance after 1–2h of needle-like endothelial cell extensions that eventually form the initial bridging of endothelial cells with each other. (B) EphrinB2 is broadly and time-dependently phosphorylated in endothelial cells as they assemble into cord-like structures. (C) The EphB receptor inhibitors SNEW and TNYL-RAW peptides prevent the assembly of endothelial cells into cord-like structures.