Table 2.
Rate of ROI specific gray matter volume change: results of the mixed-effect analysis for the comparison between iPIB-PET(+) and iPIB-PET(−) in MCI and HC
| ROI | Diagnosis | iPIB-PET group | % Annual change in volume | Δ In % annual change between iPIB-PET(−) versus iPIB-PET(+) in volume | B (SE) of Δ in annual volume change between iPIB-PET(−) versus iPIB-PET(+) in mm2/year | P value for interaction iPIB-PET × diagnosis in rate of volume change |
| Hippocampus | HC | PIB(−) | −0.9 | −0.5 | −32.1 (20.9) | ns |
| PIB(+) | −1.4 | |||||
| MCI | PIB(−) | −1.5 | −1.5 | −81.4 (18.2)** | ||
| PIB(+) | −3.0 | |||||
| Entorhinal cortex | HC | PIB(−) | −1.0 | −0.1 | 0.2 (15.4) | <0.001 |
| PIB(+) | −1.1 | |||||
| MCI | PIB(−) | −1.1 | −2.8 | −88.9 (15.7)** | ||
| PIB(+) | −3.9 | |||||
| Parahippocampus | HC | PIB(−) | −1.0 | −0.1 | −4.1 (14.6) | <0.05 |
| PIB(+) | −1.1 | |||||
| MCI | PIB(−) | −1.2 | −1.6 | −58.7 (15.3)** | ||
| PIB(+) | −2.8 | |||||
| Amygdala | HC | PIB(−) | 0.4 | −1.9 | −38.6 (14.7)** | ns |
| PIB(+) | −1.3 | |||||
| MCI | PIB(−) | −0.9 | −1.7 | −29.9 (911.7)* | ||
| PIB(+) | −2.6 | |||||
| Middle temporal gyrus | HC | PIB(−) | −1.0 | −0.5 | −92.6 (62.0) | <0.01 |
| PIB(+) | −1.4 | |||||
| MCI | PIB(−) | −0.8 | −2.4 | −424 (71.9)*** | ||
| PIB(+) | −3.1 | |||||
| Superior temporal gyrus | HC | PIB(−) | −0.9 | −0.3 | −67.0 (51.7) | ns |
| PIB(+) | −1.2 | |||||
| MCI | PIB(−) | −0.9 | −1.3 | −241.8 (63.2)** | ||
| PIB(+) | −2.2 | |||||
| Inferior parietal lobe | HC | PIB(−) | −1.0 | −0.3 | −75.7 (83.6) | <0.05 |
| PIB(+) | −1.3 | |||||
| MCI | PIB(−) | −0.6 | −1.7 | −358.5 (88.1)*** | ||
| PIB(+) | −2.3 | |||||
| Precuneus | HC | PIB(−) | −0.8 | −0.5 | −74.4 (49.8) | ns (P = 0.06) |
| PIB(+) | −1.3 | |||||
| MCI | PIB(−) | −0.6 | −1.4 | −221.4 (958.2)*** | ||
| PIB(+) | −2.0 | |||||
| Thalamus | HC | PIB(−) | −0.7 | −0.1 | −23.0 (51.3) | ns |
| PIB(+) | −0.8 | |||||
| MCI | PIB(−) | −0.7 | −0.9 | −115.3 (SE = 44)** | ||
| PIB(+) | −1.6 |
Note: B, regression coefficient; SE, standard error of regression coefficient; ns, not significant. P value for comparison of rates of changes between iPIB-PET(+) versus iPIB-PET(−) in each diagnostic group: *<0.05, **<0.01, ***<0.001.