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CPC is downregulated in MLL5-depleted cells as a result of proteasome-mediated degradation. (A) CPC was delocalized in MLL5-depleted cells. Scale bars: 10 µm. (B) NC-siRNA- and MLL5-siRNA-siRNA-transfected cells were synchronized to S, G2 or M phase. The expression of Aurora-B, Survivin, Borealin and INCENP was analyzed by western blotting. Tubulin served as a loading control. (C) Blocking of the proteasome pathway by MG132 was able to rescue the expression of all CPC components.
