Table 3.
Cox proportional hazards models of serum total cholesterol and risk of prostate cancer stratified by follow-up time, ATBC Study, 1985 – 2006
| <10 years follow-up | ≥ 10 years follow-up | |||||
|---|---|---|---|---|---|---|
| Total Cholesterol (mg/dL) | <200 | 200 - <240 | ≥240 | <200 | 200 - <240 | ≥240 |
| All Prostate Cancer | ||||||
| # cases | 129 | 183 | 300 | 219 | 486 | 724 |
| HR (95% CI)a | 1.0 (ref) | 0.75 (0.60 – 0.95) | 0.95 (0.75 – 1.21) | 1.0 (ref) | 1.07 (0.91 – 1.26) | 1.22 (1.03 – 1.44) |
| p trend = 0.66 | p trend =0.01 | |||||
| Non-Aggressive Prostate Cancer | ||||||
| # cases | 78 | 107 | 177 | 68 | 178 | 221 |
| HR (95% CI)a | 1.0 (ref) | 0.72 (0.54 – 0.98) | 0.94 (0.69 – 1.28) | 1.0 (ref) | 1.28 (0.96 – 1.70) | 1.21 (0.89 – 1.64) |
| p trend = 0.75 | p trend = 0.46 | |||||
| Aggressive Prostate Cancer | ||||||
| # cases | 51 | 74 | 120 | 30 | 75 | 111 |
| HR (95% CI)a | 1.0 (ref) | 0.75 (0.52 – 1.09) | 0.94 (0.64 – 1.37) | 1.0 (ref) | 1.32 (0.85 – 2.03) | 1.64 (1.04 – 2.60) |
| p trend =0.86 | p trend =0.03 | |||||
| Stage ≥3 | ||||||
| # cases | 49 | 64 | 113 | 25 | 58 | 103 |
| HR (95% CI)a | 1.0 (ref) | 0.69 (0.47 – 1.00) | 0.94 (0.64 – 1.39) | 1.0 (ref) | 1.23 (0.76 – 1.98) | 1.85 (1.13 – 3.03) |
| p trend =0.71 | p trend =0.005 | |||||
| Gleason Sum ≥7 | ||||||
| # cases | 17 | 34 | 47 | 15 | 57 | 61 |
| HR (95% CI)a | 1.0 (ref) | 1.03 (0.57 – 1.87) | 1.05 (0.57 – 1.94) | 1.0 (ref) | 1.75 (0.98 – 3.11) | 1.32 (0.72 – 2.45) |
| p trend =0.89 | p trend =0.94 | |||||
a
Adjusted for age (continuous), serum α-tocopherol, family history of prostate cancer, education, and urban residence.