Table 2.
Age-adjusted odds ratios for prevalent colorectal adenoma by quintile of tissue folate concentration among 813 women in the CONCeRN Study.
| Q1 < 0.442 µg/g wet tissue |
Q2 0.442–0.679 µg/g wet tissue |
Q3 0.680–0.917 µg/g wet tissue |
Q4 0.918–1.261 µg/g wet tissue |
Q5 ≥ 1.262 µg/g wet tissue |
p trend | |
|---|---|---|---|---|---|---|
| Any adenoma (N=170 cases) | ||||||
| Cases | 40 | 33 | 30 | 34 | 33 | |
| OR (95% CI) | 1.00 (reference) | 0.77 (0.45–1.31) | 0.63 (0.37–1.09) | 0.72 (0.42–1.22) | 0.68 (0.40–1.16) | 0.53 |
| Non-advanced adenoma (N=133 cases) | ||||||
| Cases | 31 | 23 | 23 | 26 | 30 | |
| OR (95% CI) | 1.00 (reference) | 0.69 (0.38–1.26) | 0.64 (0.35–1.16) | 0.73 (0.41–1.30) | 0.82 (0.46–1.44) | 0.83 |
| Advanced adenoma (N=37 cases) | ||||||
| Cases | 9 | 10 | 7 | 8 | 3 | |
| OR (95% CI) | 1.00 (reference) | 1.05 (0.41–2.73) | 0.62 (0.22–1.74) | 0.69 (0.25–1.89) | 0.24 (0.06–0.93) | 0.049 |
1
All models adjust for age. Adjusting for diabetes status, regular aspirin use, education, smoking, menopausal hormone therapy, physical activity, alcohol, dietary calcium, calcium from supplements, dietary fiber, red meat intake, or body mass index did not substantially modify these results (i.e., no point estimate differed by more than 10% from the age-adjusted odds ratio).