Table 3.

Age-adjusted odds ratios for prevalent colorectal adenoma at specific anatomic locations by quintile of tissue folate concentration among 813 women in the CONCeRN Study.

		OR (95% CI)1
	Q1 < 0.442 µg/g wet tissue	Q2 0.442–0.679 µg/g wet tissue	Q3 0.680–0.917 µg/g wet tissue	Q4 0.918–1.261 µg/g wet tissue	Q5 ≥ 1.262 µg/g wet tissue	p trend
Distal adenoma (N=60 cases)2
Cases	11	10	11	15	13
OR (95% CI)	1.00 (reference)	0.85 (0.35–2.07)	0.86 (0.36–2.07)	1.19 (0.53–2.72)	1.01 (0.43–2.37)	0.61
Proximal adenoma (N=95 cases)2
Cases	26	21	15	15	18
OR (95% CI)	1.00 (reference)	0.75 (0.40–1.42)	0.48 (0.24–0.96)	0.49 (0.24–0.97)	0.56 (0.29–1.09)	0.11
Both proximal and distal adenoma (N=15 cases)2
Cases	3	2	4	4	2
OR (95% CI)	1.00 (reference)	0.63 (0.10–3.87)	1.05 (0.23–4.85)	1.02 (0.22–4.74)	0.47 (0.08–2.94)	0.42

¹All models adjust for age. Adjusting for diabetes status, regular aspirin use, education, smoking, menopausal hormone therapy, physical activity, alcohol, dietary calcium, calcium from supplements, dietary fiber, red meat intake, or body mass index did not substantially modify these results (i.e., no point estimate differed by more than 10% from the age-adjusted odds ratio).

²In models of distal adenomas, case subjects were defined as those with only distal adenomas. Similarly, in models of proximal adenomas, case subjects were defined as those with only proximal adenomas. Subjects with both distal and proximal adenomas were categorized separately.