Table 4.
Age-adjusted odds ratios for prevalent hyperplastic polyps and/or colorectal adenoma at specific anatomic locations by quintile of tissue folate concentration among 813 women in the CONCeRN Study.
| OR (95% CI)1 | ||||||
|---|---|---|---|---|---|---|
| Q1 < 0.442 µg/g wet tissue |
Q2 0.442–0.679 µg/g wet tissue |
Q3 0.680–0.917 µg/g wet tissue |
Q4 0.918–1.261 µg/g wet tissue |
Q5 ≥ 1.262 µg/g wet tissue |
p trend | |
| Hyperplastic polyps only (any subsite) (N= 95 cases)2 | ||||||
| Cases | 19 | 12 | 20 | 22 | 22 | |
| OR (95% CI) | 1.00 (reference) | 0.60 (0.28–1.28) | 1.02 (0.52–2.00) | 1.13 (0.58–2.18) | 1.12 (0.58–2.17) | 0.51 |
| Hyperplastic polyps (any subsite); may also have adenoma (any subsite) (N=140 cases)2 | ||||||
| Cases | 31 | 20 | 27 | 32 | 30 | |
| OR (95% CI) | 1.00 (reference) | 0.60 (0.32–1.09) | 0.80 (0.45–1.42) | 0.97 (0.56–1.69) | 0.89 (0.51–1.56) | 0.45 |
| Hyperplastic polyps (any subsite) and/or proximal adenoma (N=215 cases) | ||||||
| Cases | 50 | 35 | 41 | 44 | 45 | |
| OR (95% CI) | 1.00 (reference) | 0.60 (0.36–1.01) | 0.70 (0.42–1.14) | 0.75 (0.46–1.22) | 0.76 (0.47–1.24) | 0.89 |
| Hyperplastic polyps (proximal location) and/or proximal adenoma (N=147 cases) | ||||||
| Cases | 39 | 27 | 27 | 27 | 27 | |
| OR (95% CI) | 1.00 (reference) | 0.62 (0.36–1.08) | 0.57 (0.33–1.00) | 0.55 (0.32–0.97) | 0.54 (0.31–0.95) | 0.18 |
1
All models adjust for age. Adjusting for diabetes status, regular aspirin use, education, smoking, menopausal hormone therapy, physical activity, alcohol, dietary calcium, calcium from supplements, dietary fiber, red meat intake, or body mass index did not substantially modify these results (i.e., no point estimate differed by more than 10% from the age-adjusted odds ratio).