Table 2.
PK parameters of diclofenac in female Yorkshire-Landrace pigs following oral administration or dermal patch application
| Route | Matrix (side) | Cmax (ng/mL or ng/g) | Tmax (h) | AUC(0–11.5 h) (ng · h/mL or ng · h/g) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| Mean | SD | n | Mean | SD | n | Mean | SD | n | ||
| Oral | Plasma | 9640 | 906 | 6 | 2 | 0 | 6 | 46,000 | 4817 | 6 |
| Muscle | 1160 | 256 | 6 | 2 | 0 | 6 | 5867 | 1455 | 6 | |
| Skin | 1500 | 319 | 6 | 3.3 | 1.4 | 6 | 9600 | 1817 | 6 | |
| Dermal | Plasma | 3.49 | 5.57 | 6 | 5.3 | 5 | 6 | 25.2 | 39.0 | 6 |
| Muscle (treated) | 879 | 632 | 6 | 6.7 | 4.2 | 6 | 4117 | 2633 | 6 | |
| Muscle (untreated) | 0.652 | 0.926 | 6 | 4.2 | 3.2 | 6 | 5.0 | 6.7 | 6 | |
| Skin (treated) | 19,200 | 2350 | 6 | 5.2 | 3 | 6 | 161,167 | 24,333 | 6 | |
| Skin (untreated) | 2.4 | 2.51 | 6 | 4.2 | 3.2 | 6 | 14.3 | 15.6 | 6 | |
Notes: Treated: dermal patch applied to the right-dorsal lumbar region; untreated: samples obtained but no patch was administered.
Abbreviations: PK, pharmacokinetic; Cmax, highest drug concentration observed in plasma/tissues; Tmax, time at which Cmax was first observed; AUC(0–11.5 h), area under the plasma/tissue drug concentration-time curve for 0–11.5 hours.