TABLE 2.

Complete list of the transcription factor-binding sites predicted in the tissue factor promoter-PAK1 interacting region using Promo 3.0 software analysis

The transcription factors selected for EMSA are highlighted.

Transcription factor	No. of sites	Activator/repressor	Function
TCF-4E (T02878)	2	Activator	Associated with reduced survival in estrogen receptor-α breast cancer cells
			Positive regulation of epithelial cell proliferation
GR (T05076)	1	Activator/repressor	Regulation of genes controlling development, metabolism, and immune response
GR-β (T01920)	14	Activator/repressor
GR-α (T00337)	7	Activator/repressor
XBP-1 (T00902)	1	Activator	Immune system and cellular stress response
AP-2αA (T00035)	4	Activator/repressor	Differentiation and development of neural crestal cells
C/EBPβ(T00581)	19	Repressor	Inflammatory and immune responses
HOXD9 (T01424)	2	Activator	Morphogenesis
HOXD10 (T01425)	2	Activator	Differentiation and limb development
TFIID (T00820)	1	Activator	Basal transcription and transcription initiation
FOXP3 (T04280)	2	Repressor	Immune system responses
YY1 (T00915)	2	Activator/repressor	Proposed core component of chromatin remodeling complexes
GATA-1 (T00306)	2	Activator	Platelet aggregation and formation
			Cell growth and cancer
TFII-I (T00824)	2	Activator/repressor	Growth factor signaling. Implications in cancer
HNF-1A (T00368)	1	Activator	Liver-specific genes. Glucose homeostasis
PXR-1:RXR-α (T05671)	1	Activator/repressor	Assembly of functional peroxisomes (PXR-1)
			Mediator of retinoids (RXR-α)
c-Ets-1 (T00112)	1	Activator/repressor	Stem cell development, cell senescence and death, and tumorigenesis
STAT4 (T01577)	1	Activator	Mediation of cellular responses to IL-12 in T-lymphocytes
			Signaling molecule for TH1 differentiation
AP-1 (T00029)	1	Activator	Differentiation, proliferation, and apoptosis
c-Jun (T00133)	1
LEF-1 (T02905)	1	Activator	Wnt signaling