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. 2012 Sep 28;287(47):39812–39823. doi: 10.1074/jbc.M112.406520

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — c-Met downstream pathways promote proliferation and invasion of human cholangiocarcinoma cells. A, PI3K/Akt and MEK/ERK inhibition inhibit human cholangiocarcinoma cell proliferation. QBC939, RBE, and HCCC-9810 cells were treated with LY294002 (LY, 20 μm) and U0126 (10 μm) for the indicated time periods. Cell viability was determined by a CCK8 assay. B and C, PI3K/Akt and MEK/ERK inhibition suppress migration and invasion of human cholangiocarcinoma cells. The migration (C) and invasion (D) of QBC939, RBE, and HCCC-9810 cells with or without LY294002 (LY, 20 μm) and U0126 (10 μm) treatment were analyzed using a Transwell assay. Columns, mean of three individual experiments; bars, S.E. *, significantly different from control value.