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. 2012 Sep 27;287(47):39554–39563. doi: 10.1074/jbc.M112.408625

FIGURE 4.

FIGURE 4.

Increased susceptibility to LPS-induced sepsis in Adamts12−/− mice. A, variation in hematocrit during treatment. Mice lacking Adamts12 show an increased hematocrit at day 3 after LPS injection, likely as an effect of more severe dehydration, compared with wild-type animals. B, levels of leukocytes in peripheral blood after LPS injection. At day 8 after treatment, Adamts12−/− mice show an enhanced number of leukocytes. C, composition of leukocyte populations in peripheral blood after LPS treatment. At day 3, an evident deviation in leukocyte populations was observed in Adamts12−/− mice, which exhibited reduced lymphocytes and increased monocytes and granulocytes compared with control animals. At day 8, the number of neutrophils was still increased in mice lacking the metalloprotease. D, Western blot against S100A8 and S100A9 in spleens and livers from LPS-treated mice. S100A8 and S100A9 are elevated in tissues of Adamts12−/− mice 8 days after induction of sepsis. *, p < 0.05; **, p < 0.01; ***, p < 0.001.