FIGURE 5.

Increased affection of Adamts12^−/− mice after cerulein-induced pancreatitis. A, Adamts12-deficient tissues are more affected by edema during pancreatitis. Microscopic images show affected pancreas stained with hematoxylin and eosin. Edema, one of the main indicators of pancreatitis, was increased in the interacinar spaces (indicated with red arrows) of Adamts12^−/− mice after treatment with cerulein. B, increased levels of hemopexin in pancreatitis of mice deficient in Adamts12. ***, p < 0.001.