FIGURE 6.

ADAMTS-12 is expressed in neutrophils and induces their apoptosis. A, apoptosis levels of peritoneal neutrophils from Adamts12^−/− (n = 7) and Adamts12^+/+ (n = 6) mice after casein induction. B, percentage of live and apoptotic human neutrophils after co-culture with EBNA-TS12 or EBNA-control. Live cells are annexin V- and PI-negative; pre-apoptotic cells are annexin V-positive, PI-negative; apoptotic cells are annexin V- and PI-positive; and necrotic cells are annexin V-negative and PI-positive. C, RT-PCR showing murine Adamts12 expression in cDNA from WT and KO lymphocytes and neutrophils. **, p < 0.01.