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Menin excision promotes the development of K-Ras-induced lung cancer. A, the lung tissue hematoxylin and eosin staining of K-RasG12D/+ mice (C57BL/6 and 129/Sv mixed background) and Men1f/f;K-RasG12D/+ mice (K-RasG12D/+ mice crossed with Men1f/f mice) fed tamoxifen. B and C, the quantitative analysis of the number and the size of tumors in K-RasG12D/+;Cre-ER mice and Men1f/f;K-RasG12D/+;Cre-ER mice, respectively. *, p < 0.05 versus control.
