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Huntingtin PY-NLS basic region is critical for NLS activity in vivo. A, positive control of GFP-Htt NLS-β-galactosidase, compared with P207A/Y208A and K177A/K178A mutants, quantified in B. Ctrl is GFP-β-galactosidase, which has been quantified and then set as base line to 0. C and D, analysis of huntingtin NLS mutants in the (Q17)1–465-eYFP context. n = ∼50 cells quantified per construct. *, p < 0.01. Error bars, S.E.
