Table 3.
GSK3β Genotype Associations with Factor Scores in HAMA and HAMD-17
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rs6438552 |
rs7633279 |
rs334558 |
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Mean score |
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Mean score |
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Mean score |
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| Factors | CC (154) | CT (238) | TT (99) | χ2 | p | TT (136) | TA (247) | AA (138) | χ2 | p | GG (179) | GA (220) | AA (85) | χ2 | p | Adjusted p |
| HAMA-T | 17.96 | 16.98 | 19.35 | 11.13 | 0.004 | 18.46 | 16.86 | 18.99 | 12.75 | 0.002 | 17.78 | 17.66 | 19.65 | 7.083 | 0.029 | 0.010 |
| HAMA-1 | 6.20 | 5.58 | 6.95 | 10.25 | 0.006 | 6.34 | 5.66 | 6.66 | 7.017 | 0.030 | 6.15 | 5.92 | 7.11 | 6.449 | 0.040 | 0.018 |
| HAMA-2 | 11.76 | 11.40 | 12.40 | 7.121 | 0.028 | 12.13 | 11.20 | 12.34 | 14.12 | 0.001 | 11.63 | 11.75 | 12.54 | 5.13 | 0.077 | 0.003 |
| HAMD-T | 22.61 | 22.02 | 22.79 | 3.436 | 0.179 | 22.45 | 21.93 | 23.02 | 7.017 | 0.058 | 22.74 | 22.45 | 23.11 | 0.804 | 0.669 | 0.138 |
| HAMD-1 | 7.06 | 6.42 | 7.39 | 12.82 | 0.002 | 6.85 | 6.53 | 7.28 | 7.203 | 0.027 | 7.13 | 6.81 | 7.18 | 2.286 | 0.319 | 0.007 |
| HAMD-2 | 4.01 | 4.09 | 3.74 | 3.436 | 0.179 | 3.79 | 4.16 | 3.86 | 4.13 | 0.127 | 4.17 | 4.01 | 3.71 | 7.239 | 0.027 | 0.060 |
| HAMD-3 | 7.39 | 7.58 | 7.75 | 2.038 | 0.361 | 7.71 | 7.51 | 7.42 | 1.013 | 0.603 | 7.45 | 7.64 | 7.80 | 0.834 | 0.659 | 0.615 |
| HAMD-4 | 3.46 | 3.32 | 3.49 | 1.03 | 0.598 | 3.53 | 3.20 | 3.71 | 5.838 | 0.054 | 3.31 | 3.46 | 3.84 | 9.323 | 0.047 | 0.009 |
GSK3β, glycogen synthase kinase-3β; HAMD, Hamilton depression rating scale; HAMA, Hamilton anxiety rating scale; HAMA-T, HAMA total; HAMA-1, HAMA somatic anxious factor; HAMA-2, HAMA mental anxious factor; HAMD-T, HAMD Total; HAMD-1, HAMD-17 anxiety and somatization factor; HAMD-2, HAMD-17 dysgnosia factor; HAMD-3, HAMD-17 blocking factor; HAMD-4, HAMD-17 sleep factor.