Table 1. Proteins differentially expressed by cultured macrophage foam cells.
| Protein | Control Cells (spectral counts) |
Foam Cells (spectral counts) |
G- statistic* (G-test) |
P value (t-test) |
|---|---|---|---|---|
| Prosaposin (PSAP) | 23.6 | 44.3 | 6.4 | 0.018 |
| CD5 antigen-like (CD5L) | 0 | 4.4 | 6.1 | 0.0004 |
| Apolipoprotein E (APOE) | 36.9 | 58.1 | 4.9 | 0.038 |
| Cathepsin D (CTSD) | 75.1 | 97.4 | 2.9 | 0.030 |
| Complement C3 (CO3) | 22.9 | 13.4 | 2.5 | 0.030 |
| Procollagen, type I, α2 (COL1A2) | 11.6 | 5.3 | −2.5 | 0.0017 |
| Histone cluster 1 (H2BF) | 9.4 | 17.4 | −2.4 | 0.037 |
| Cathepsin L (CTSL) | 28 | 40.9 | 2.4 | 0.029 |
| Puromycin-sensitive aminopeptidase (NPEPPS) |
3.5 | 0.6 | −2.2 | 0.017 |
| Ferritin light chain 1 (FTL1) | 3.3 | 7.9 | 2.0 | 0.0060 |
| Protein phosphatase 1, catalytic subunit, gamma isoform (PPP1CC) |
0.8 | 3.4 | 1.8 | 0.014 |
| GPI-anchored a2 macroglobulin- related protein (CD109) |
9 | 4.4 | −1.6 | 0.011 |
| Complement factor properdin (PFC) | 0.5 | 2.6 | 1.6 | 0.0025 |
| Cystatin C (CYSC) | 23.8 | 33.1 | 1.6 | 0.030 |
| Colony stimulating factor 1 receptor (CSF1R) |
10 | 16.3 | 1.5 | 0.023 |
*
A positive or negative value for the G-test indicates an increased or decreased level of protein expression, respectively, relative to control macrophages.