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. 2012 Sep 18;31(22):4276–4288. doi: 10.1038/emboj.2012.250

Figure 1.

Figure 1

Mice lacking AgRP-neurons become obese on RCD. In all, 4-h feeding response after an intraperitoneal (IP) injection of saline or ghrelin (500 μg/kg) (A), or after a 24-h fast (B) in naive (black bars and circles) and AgRP-ablated mice (red bars and circles). (n=6–9 in each group). Average body weight in naive (black circles) and AgRP-ablated mice (red circles) fed on RCD (n=6–7 in each group) (C). Average food intake in kcal of chow was recorded at several time points at age 2, 4 and 6 months (black bar in Figure 1C) (n=6–7 in each group) (D). Feed efficiency is presented as mg of body weight gain/kcal consumed during a 4-month period (E). Adipose tissue weight after a 24-h fast (Visc AT: visceral adipose tissue, Sc AT: subcutaneous adipose tissue, Perirenal AT: perirenal adipose tissue, epid AT: epididymal adipose tissue) (F). Displayed values are mean values±s.e.m. *P<0.05 (n=6–7 in each group).