Figure 6.

Lack of AgRP-neurons is associated with resistance to high-fat feeding. Feed efficiency as mg of body weight gain/kcal consumed calculated during a 2-month period during an HFD regimen (A), final body weight (B), blood glucose (mg/dl) after a 5-h food deprivation (C) and after an oral charge of glucose (3 g/kg) (D, F) and plasma insulin (ng/ml) (E), in naive mice (black and grey bars) and obese AgRP-ablated mice (red and blue bars). Data were acquired on the same group of animals fed a RCD before HFD regimen (black and red bars), and after a 6-month HFD regimen (grey and blue) (n=7–8 in each group). Displayed values are mean values±s.e.m. *P<0.05.