Table IV.
Estimated percentage change in mean number of oocytes retrieved, mean number of mature oocytes (MII) and normally fertilized (2PN) oocytes by BPA quartiles and covariates (n = 174 women, 237 IVF cycles).
| Covariates | Percentage change in number of oocytes retrieved |
Percentage change in number of MII oocytes |
Percentage change in 2PN oocytes |
|||
|---|---|---|---|---|---|---|
| Unadjusted (95% CI) | Adjusteda (95% CI) | Unadjusted (95% CI) | Adjusteda (95% CI) | Unadjusted (95% CI) | Adjusteda (95% CI) | |
| BPA quartiles (range µg/l) | ||||||
| Q1 (≤1.60) | Ref | Ref | Ref | Ref | Ref | Ref |
| Q2 (1.61–2.32) | 1% (−13%, 17%) | −1% (−15%, 15%) | −6% (−20%, 9%) | −9% (−21%, 6%) | −7% (−23%, 12%) | −9% (−25%, 10%) |
| Q3 (2.33–3.76) | −4% (−18%, 13%) | −6% (−20%, 10%) | −8% (−22%, 8%) | −10% (−24%, 5%) | −10% (−26%, 8%) | −13% (−27%, 5%) |
| Q4 (≥3.77) | −21% (−32%, −8%) | −24% (−34%, −11%) | −27% (−38%, −14%) | −29% (−39%, −17%) | −27% (−39%, −11%) | −28% (−40%, −13%) |
| Test for trend (P-value) | 0.003 | <0.001 | <0.001 | <0.001 | 0.002 | <0.001 |
| Age (≥37 versus <37 year) | −18% (−29%, −6%) | −17% (−27%, −4%) | −16% (−27%, −4%) | −15% (−25%, −3%) | −19% (−30%, −5%) | −17% (−28%, −4%) |
| BMI (≥25 versus <25 kg/m2) | 3% (−11%, 18%) | 2% (−11%, 17%) | 3% (−10%, 18%) | 4% (−9%, 18%) | −2% (−16%, 15%) | −1% (−15%, 16%) |
| Day 3 FSH (≥12 versus <12 IU/l) | −49% (−61%, −33%) | −49% (−61%, −34%) | −46% (−63%, −23%) | −45% (−61%, −21%) | −49% (−64%, −25%) | −47% (−60%, −29%) |
| IVF protocol (flare/ant. versus luteal) | −36% (−44%, −27%) | — | −34% (−42%, −24%) | — | −35% (−43%, −25%) | — |
| Ever versus never smoker | −2% (−15%, 14%) | — | −6% (−19%, 8%) | — | 0% (−15%, 17%) | — |
Ref., reference group.
aAdjusted for age, BMI, Day 3 FSH.