Table IV.
Mean changes in ASUI scores as a function of changes in percent predicted FEV1 values and ACQ scores
| N (pts.)** | Mean change in ASUI (95% CI) | P value | ||
|---|---|---|---|---|
| Changes in percent predicted FEV1 | ||||
| Better (ΔFEV1 ≥ 10%) | 213 (163) | 0.05 (0.03, 0.07) | ||
| Same (−10% ≤ ΔFEV1 <10%) | 1657 (384) | 0.01 (0.00, 0.01) | ||
| Worse (ΔFEV1 ≤−10%) | 222 (170) | −0.03 (−0.05, −0.02) | <0.0001 | |
| Changes in ACQ* (Δ ACQ) | ||||
| Better | ΔACQ ≥ −1.5 | 76 (68) | 0.32 (0.28, 0.35) | |
| −1.0 ≤ ΔACQ < −1.5 | 111 (100) | 0.15 (0.13, 0.18) | ||
| −0.5 ≤ ΔACQ < −1.0 | 255 (198) | 0.09 (0.08, 0.10) | ||
| Same | +0.5 > ΔACQ < −0.5 | 1254 (369) | 0.00 (−0.00, 0.01) | |
| Worse | +1.0 > ΔACQ ≥ +0.5 | 233 (175) | −0.09 (−0.10, −0.07) | |
| +1.5 > ΔACQ ≥ +1.0 | 78 (69) | −0.17 (−0.20, −0.14) | ||
| ΔACQ ≥ + 1.5 | 61 (53) | −0.32 (−0.36, −0.28) | <0.0001 | |
Note: MID for ACQ is 0.5 points
ACQ: Asthma Control Ques ionnaire, ASUI: Asthma Symptom Utility Index, FEV1: Forced expiratoryvolume in the first second
*
ACQ: Better = decrease by ≥ 0.5 points; same = change by <0.5 points; Worse = increase by ≥ 0.5 points.
**
N denotes frequency of events and “pts.” indicates the number of patients