Table 3. Association of high myopia in the Chaoshan and Guangzhou population groups.

Guangzhou
Region	SNP	Test	Myopia (300 total)	Control (308 total)	Odds ratio*	P**
15q14	rs634990	AA	73	125	1	1.91×10−5
		GA	156	144	1.86 (1.29–2.68)	0.2
		GG	71	39	3.12 (1.92–5.07)	4.25×10−4
		G allele %	0.5	0.36	1.75 (1.39–2.20)	1.57×1−6
		Additive				1.45×10−6
	rs634990	AA	69	125	1	3.31×10−6
		TA	161	143	2.04 (1.41–2.95)	0.07
		TT	70	40	3.17 (1.95–5.16)	9.22×10−4
		T allele %	0.5	0.36	1.78 (1.41–2.23)	8.8×10−7
		Additive				7.01×10−7
15q25	rs8027411	TT	113	108	1	0.5
		GT	146	151	0.92 (0.65–1.31)	0.92
		GG	41	49	0.80 (0.49–1.31)	0.44
		G allele %	0.38	0.4	0.90 (0.72–1.14)	0.39
		Additive				0.38
	rs17175798	CC	112	107	1	0.51
		TC	148	152	0.93 (0.66–1.32)	0.99
		TT	40	49	0.78 (9.48–1.28)	0.37
		T allele %	0.38	0.4	0.90 (0.71–1.30)	0.36
		Additive				0.35
	rs939658	CC	121	116	1	0.5
		TC	139	147	0.93 (0.66–1.32)	0.73
		TT	40	45	0.91 (0.69–1.30)	0.65
		T allele %	0.37	0.39	0.92 (0.73–1.16)	0.36
		Additive				0.48

Chaoshan
Region	SNP	Genotype	Myopia (96 total)	Control (96 total)	Odds Ratio	P**
15q14	rs634990	AA	28	34	1	0.35
		GA	48	46	1.26 (0.67–2.41)	0.77
		GG	20	16	1.51 (0.66–3.47)	0.46
		G allele %	0.46	0.41	1.23 (0.83–1.85)	0.3
		Additive				0.3
	rs524952	AA	28	34	1	0.35
		TA	48	46	1.26 (0.67–2.41)	0.77
		TT	20	16	1.52 (0.66–3.47)	0.46
		T allele %	0.46	0.41	1.24 (0.83–1.35)	0.3
		Additive				0.3
15q25	rs8027411	TT	37	26	1	0.09
		GT	44	54	0.57 (0.30–1.08)	0.15
		GG	14	15	0.66 (0.27–1.59)	0.84
		G allele %	0.38	0.44	0.79 (0.52–1.19)	0.21
		Additive				0.2
	rs17175798	CC	37	27	1	0.13
		TC	44	53	0.61 (0.32–1.15)	0.19
		TT	14	15	0.68 (0.28–1.64)	0.84
		T allele %	0.41	0.38	0.79 (0.52–1.18)	0.25
		Additive				0.24
	rs939658	CC	35	31	1	0.68
		TC	48	50	0.93 (0.66–1.32)	0.77
		TT	13	15	0.91 (0.69–1.30)	0.54
		T allele %	0.37	0.39	0.92 (0.73–1.16)	0.53
		Additive				0.52

Combined
Region	SNP	Genotype	Myopia (396 total)	Control (404 total)	Odds Ratio*	P**
15q14	rs634990	AA	97	159	1	6.63×10−6
		GA	209	189	1.81 (1.32–2.50)	0.09
		GG	90	56	2.63 (1.73–4.00)	0.001
		G allele %	0.49	0.37	1.75 (1.39–2.20)	1.66×10−6
		Additive				1.42×10−6
	rs524952	AA	101	159	1	2.89×10−5
		TA	204	190	1.69 (1.23–2.32)	0.2
		TT	91	55	2.60 (1.72–3.95)	6.10×10−4
		T allele %	0.49	0.37	1.78 (1.41–2.23)	2.72×10−6
		Additive				2.59×10−6
15q25	rs8027411	TT	150	134	1	0.16
		GT	190	205	0.83 (0.61–1.12)	0.43
		GG	55	64	0.77 (0.50–1.18)	0.44
		G allele %	0.38	0.41	0.90 (0.72–1.14)	0.17
		Additive				0.17
	rs17175798	CC	149	134	1	0.38
		TC	192	205	0.84 (0.62–1.14)	0.52
		TT	54	64	0.75 (0.49–1.17)	0.19
		T allale %	0.38	0.41	0.90 (0.71–1.13)	0.17
		Additive				0.16
	rs939658	CC	156	147	1	0.55
		TC	187	197	0.93 (0.66–1.32)	0.66
		TT	53	60	0.83 (0.54–1.28)	0.38
		T allele %	0.37	0.39	0.91 (0.74–1.11)	0.37
		Additive				0.35

* Relative to major allele, or major allele homozygote **p<0.00066 is significant, corresponding to a p<0.-05 after Bonferroni correction for 76 tests.