Table 4. Haplotype analysis of high myopia in the Chaoshan and Guangzhou population groups.
| Guangzhou | |||||||
|---|---|---|---|---|---|---|---|
| SNPs | r2 | D' | Haplotype | Myopia (300 total) | Control (308 total) | Odds ratio | p** |
|
rs634990 |
0.95 |
0.98 (0.96 - 1) |
AA |
0.49 |
0.64 |
0.57 (0.45–0.71) |
1.20×10−6 |
| rs524952 | GT | 0.49 | 0.36 | 1.76 (1.40–2.23) | |||
| Chaoshan | |||||||
|---|---|---|---|---|---|---|---|
| SNPs | r2 | D' | Haplotype | Myopia (96 total) | Control (96 total) | Odds ratio | p** |
|
rs634990 |
1 |
1 (0.98 - 1) |
AA |
0.54 |
0.59 |
0.81 (0.54–1.21) |
0.3 |
| rs524952 | GT | 0.46 | 0.41 | 1.24 (0.82–1.85) | |||
| Combined |
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|
| SNPs | r2 | D' | Haplotype | Myopia (396 total) | Control (404 total) | Odds Ratio | p** |
|
rs634990 |
0.96 |
0.99 (0.97 - 1) |
AA |
0.5 |
0.63 |
0.62 (0.51–0.75) |
2.20×10−6 |
| rs524952 | GT | 0.48 | 0.37 | 1.62 (1.33–1.98) |
**p<0.00066 is significant, corresponding to a p<0.-05 after Bonferroni correction for 76 tests