Table 5. Summary of association of myopia with markers on chromosome 15q14 and 15q25 from the literature and the present study.
Locus | best SNPs* | Gene(s) | Study | Population | best P | best OR |
---|---|---|---|---|---|---|
15q14 |
rs634990
rs524952 |
GOLGA8B ACTC1 GJD2 |
Solouki et al. [57] |
European |
2.21×10−14 |
1.81 (1.42–2.36)# |
|
rs634990
rs524952 |
Hayashi et al. [36] |
Japanese |
8.781×10−7 |
1.32 (1.11–1.56) |
|
|
rs634990 |
|
Verhoeven et al. [37]** |
European Japanese Singapore |
9.2×10−23^ |
1.88 (1.64–2.16)# |
|
rs634990 |
|
|
European |
3.87×10−12^ |
na |
|
rs8032019 |
|
Asian |
9.65×10−4^ |
na |
|
|
rs634990 |
|
present study |
Han Chinese |
1.66×10−6+ |
1.75 (1.39–2.20) |
15q25 |
rs8027411
rs939658 |
RASGRF1 |
Hysi et al. [31] |
European |
2.07×10−9 |
1.16 (1.02–1.28)# |
|
rs8027411
rs939658 |
Hayashi et al. [36] |
Japanese |
0.031 |
1.17 (1.03–1.33) |
|
|
rs939661 |
|
Verhoeven et al. [37]** |
European Japanese Singapore |
1.22×10−4& |
na |
rs8027411 | present study | Han Chinese | 0.17+ | 0.9 (0.72–1.14) |
* not exhaustive; **meta-analysis including results of Hysi et al. and Soluki et al. with others; ^ p<3.56×10–3 considered significant after Bonferroni correction; & p<1.92×10–3 considered significant after Bonferroni correction; # OR for homozygous carriers not available; na not available; +p<0.00066 is considered significant after Bonferroni correction