Figure 2.
Schematic illustrations displaying non-autonomous effects of clones of different genetic backgrounds in Drosophila wings. Orientation of cells surrounding mutant clones is indicated by arrows (black arrows for normal orientation and orange arrows for repolarized orientation). The mutant cells themselves (marked by red fields) show random orientation, which is not indicated by additional means. (a) Wild-type (wt) clone does not change polarity (for comparison). (b) dsh− mutant clone causes polarity defects within mutant cells but does not affect the polarity of neighboring cells (black arrows). (c) fz− mutant clone causes wild-type distal neighboring cells to reverse polarity and point toward the clone (orange arrows). (d) Vang− mutant clone causes proximal wild-type neighboring cells to reverse polarity and point away from mutant tissue (orange arrows). (e) Fz overexpressing clone (fz2+) causes neighboring cells to point away from clone (orange arrows). (f) fz−, Vang− double mutant clone causes neighboring wild-type cells to point towards mutant tissue (orange arrows; very similar to fz− mutant clones). (g) fmi− mutant clone has polarity defects inside mutant tissue but does not affect polarity of wild-type neighboring cells. (h) fmi overexpressing clone (fmi2+) causes wild-type neighboring cells to point toward the clone (orange arrows; similar to fz− mutant patches). See main text for discussion.