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. 2012 Nov 19;209(12):2149–2156. doi: 10.1084/jem.20121274

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© 2012 Kim et al.

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Figure 5. — Modulation of microglia activity by anti-apoE antibody treatment. APPswe/PS1ΔE9 mice were intraperitoneally injected with PBS vehicle or anti-apoE antibody (HJ6.3; 10 mg/kg) 4 times every 3 d. (A and B) Brain sections were immunostained for activated microglia with anti-CD45 antibody. Bar, 150 µm. (C) The extent of microglial recruitment around plaques in cortex was quantified after normalizing with X-34–positive fibrillar plaque load. (D and E) Levels of proinflammatory cytokines (IFN-γ and IL-1α) in the cortex were measured by Rodent Cytokine Multi-Analyte Profile assay. n = 11 for PBS group; n = 9 for HJ6.3 group. Variance represents SEM.