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. 2012 Nov 19;209(12):2277–2290. doi: 10.1084/jem.20120350

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© 2012 Althoff et al.

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Figure 5. — Effect of Sm-specific Gα deficiencies on vascular response to femoral artery injury. (A and B) 4 wk after femoral artery injury, femoral arteries from WT, Sm-12/13-KO, or Sm-q/11-KO mice were isolated and sectioned as described in Materials and methods. Shown are representative sections (A) and an evaluation of the neointima and media areas (n = 4; B). Shown are mean values ± SEM; *, P < 0.05; ***, P < 0.001 (compared with WT). (C) 7 d after femoral artery injury, femoral arteries from WT, Sm-12/13-KO, or Sm-q/11-KO mice were isolated. Shown are immunohistochemical analyses performed with an antibody against α-SMA. Boxes indicate magnified areas at the bottom of each panel. (A–C) Shown is one representative of at least three experiments. Bars: (A and C [top]) 100 µm; (C, bottom) 40 µm.