Table II.
Alterations in gene expression (fold-change) induced by propranolol treatment.
| Gene symbol | Gene name | Accession no. | HIHEC | HDMVEC | HCAEC |
|---|---|---|---|---|---|
| HMGCS1 | 3-Hydroxy-3-methylglutaryl-CoA synthase 1 | NM_002130.6 | 4.6 | 5.8 | 6.2 |
| MSMO1 | Methylsterol monooxygenase 1, TV2 | NM_001017369.2 | 4.5 | 4.0 | 5.8 |
| INSIG1 | Insulin induced gene 1 | NM_198336.2 | 4.3 | 4.6 | 4.9 |
| LDLR | Low density lipoprotein receptor | NM_000527.4 | 3.6 | 3.8 | 3.9 |
| MVD | Mevalonate decarboxylase | NM_002461.1 | 3.6 | 5.7 | 3.4 |
| DHCR7 | 7-Dehydrocholesterol reductase | NM_001360.2 | 3.6 | 4.7 | 3.4 |
| SCD | Stearoyl-CoA desaturase | NM_005063.4 | 3.3 | 3.2 | 5.0 |
| ACAT2 | Acetyl-CoA acetyltransferase 2 | NM_005891.2 | 3.2 | 4.6 | 5.2 |
| LSS | Lanosterol synthase | NM_002340.5 | 3.2 | 4.5 | 5.1 |
| TM7SF2 | Transmembrane 7 superfamily member 2 | NM_003273.2 | 3.0 | 4.8 | 5.2 |
| HMGCR | 3-Hydroxy-3-methylglutaryl-CoA reductase | NM_000859.2 | 2.9 | 3.1 | 3.8 |
| FASN | Fatty acid synthase | NM_004104.4 | 2.8 | 4.6 | 4.3 |
| MSMO1 | Methylsterol monooxygenase 1, TV1 | NM_006745.4 | 2.8 | 2.0 | 3.0 |
| SQLE | Squalene epoxidase | NM_003129.3 | 2.7 | 2.6 | 3.6 |
| PSG4 | Pregnancy specific β-1-glycoprotein 4 | NM_002780.3 | 2.6 | 1.3 | 4.5 |
| DHCR24 | 24-Dehydrocholesterol reductase | NM_014762.3 | 2.5 | 2.4 | 3.3 |
| FDFT1 | Farnesyl-diphosphate farnesyltransferase 1 | NM_004462.3 | 2.5 | 2.2 | 3.2 |
| IDI1 | Isopentenyl-diphosphate δ isomerase 1 | NM_004508.2 | 2.4 | 2.3 | 3.4 |
| FADS2 | Fatty acid desaturase 2 | NM_004265.2 | 2.4 | 4.2 | 2.8 |
| NPC1 | Niemann-Pick disease, type C1 | NM_000271.4 | 2.3 | 2.3 | 3.8 |
| PFKFB4 | Fructose-2,6-biphosphatase 4 | NM_004567.2 | 2.2 | 2.8 | 2.3 |
| ACSS2 | Acyl-CoA synthetase family member 2, TV2 | NM_001076552.2 | 2.2 | 2.6 | 3.5 |
| ACSS2 | Acyl-CoA synthetase family member 2, TV1 | NM_018677.3 | 2.2 | 2.7 | 3.2 |
| EBP | Emopamil binding protein | NM_006579.2 | 2.1 | 2.4 | 2.3 |
| LOC100129668 | LOC100129669 | XM_001713607.1 | 2.1 | 2.2 | 2.5 |
| HMOX1 | Heme oxygenase (decycling) 1 | NM_002133.2 | 2.1 | 2.1 | 3.5 |
| SC5DL | Sterol-C5-desaturase-like | NM_006918.4 | 2.1 | 1.4 | 2.4 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | NM_015922.2 | 2.1 | 2.3 | 2.2 |
| P2RX4 | Purinergic receptor P2X, 4 | NM_002560.2 | 2.1 | 1.7 | 1.8 |
| LPIN1 | Lipin 1 | NM_145693.1 | 2.0 | 1.6 | 2.9 |
| PGF | Placental growth factor | NM_002632.5 | 2.0 | 1.7 | 2.3 |
| ANGPT2 | Angiopoietin 2 | NM_001147.2 | 2.0 | 1.0 | 2.1 |
| LOC729009 | LOC729010 | XR_042330.1 | 2.0 | 1.6 | 2.6 |
| IL8 | Interleukin 8 | NM_000584.3 | −2.0 | −2.9 | −3.1 |
| CDK1 | Cyclin-dependent kinase 1 | NM_001786.4 | −2.0 | −1.8 | −2.1 |
| TUBB2C | Tubulin, β 4B Ivb | NM_006088.5 | −2.0 | −1.4 | −2.5 |
| PTTG1 | Pituitary tumor-transforming 1 | NM_004219.2 | −2.0 | −2.0 | −2.0 |
| OIP5 | Opa interacting protein 5 | NM_007280.1 | −2.0 | −2.3 | −2.1 |
| CDCA8 | Cell division cycle associated 8 | NM_018101.3 | 2.0 | −1.4 | −2.3 |
| TAGLN | Transgelin | NM_003186.3 | −2.0 | −1.7 | −2.9 |
| CDKN3 | Cyclin-dependent kinase inhibitor 3 | NM_005192.3 | −2.0 | −1.7 | −1.6 |
| ANLN | Anillin, actin binding protein | NM_018685.2 | −2.0 | −1.8 | −1.7 |
| HJURP | Holliday junction recognition protein | NM_018410.3 | −2.0 | −1.2 | −2.0 |
| PBK | PDZ binding kinase | NM_018492.2 | −2.0 | −1.6 | −2.5 |
| UBE2T | Ubiquitin-conjugating enzyme E2T (putative) | NM_014176.3 | −2.0 | −1.4 | −1.5 |
| STEAP1 | 6-Transmembrane epithelial antigen of the prostate 1 | NM_012449.2 | −2.0 | −1.8 | −1.8 |
| UBE2C | Ubiquitin-conjugating enzyme E2C, TV3 | NM_181800.1 | −2.0 | −1.9 | −2.8 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | NM_001826.2 | −2.0 | −1.6 | −1.9 |
| TACC3 | Transforming, acidic coiled-coil containing protein 3 | NM_006342.2 | −2.0 | −1.4 | −1.8 |
| NCAPG | Non-SMC condensin I complex, subunit G | NM_022346.3 | −2.0 | −1.7 | −1.6 |
| PCDH7 | Protocadherin 7 | NM_002589.2 | −2.0 | −1.2 | −2.2 |
| FAM64A | Family with sequence similarity 64, member A | NM_019013.2 | −2.1 | −1.2 | −2.0 |
| PRC1 | Protein regulator of cytokinesis 1 | NM_199413.1 | −2.1 | −1.5 | −2.3 |
| MELK | Maternal embryonic leucine zipper kinase | NM_014791.3 | −2.1 | −1.8 | −2.1 |
| TPX2 | TPX2, microtubule-associated | NM_012112.4 | −2.1 | −1.4 | −2.2 |
| MCM4 | Minichromosome maintenance complex CMPT 4, TV2 | NM_182746.2 | −2.1 | −1.6 | −1.9 |
| ZWINT | ZW10 interactor | NM_001005413.1 | −2.1 | −1.5 | −2.0 |
| KIFC1 | Kinesin family member C1 | NM_002263.2 | −2.1 | −1.4 | −2.2 |
| CDC20 | Cell division cycle 20 | NM_001255.2 | −2.2 | −2.0 | −4.0 |
| UBE2C | Ubiquitin-conjugating enzyme E2C, TV6 | NM_181803.1 | −2.2 | −1.8 | −2.4 |
| NCAPG2 | Non-SMC condensin II complex, subunit G2 | NM_017760.5 | −2.2 | −1.3 | −1.4 |
| SERPIND1 | Serpin peptidase inhibitor, clade D, member 1 | NM_000185.3 | −2.2 | −1.8 | −2.6 |
| CDC45L | Cell division cycle 45 | NM_003504.3 | −2.2 | −1.8 | −3.0 |
| LYAR | Ly1 antibody reactive | NM_017816.2 | −2.2 | −1.6 | −1.3 |
| CCNA1 | Cyclin A1 | NM_003914.3 | −2.2 | −2.2 | −1.9 |
| TRIP1 | Thyroid hormone receptor interactor 13 | NM_004237.3 | −2.2 | −1.9 | −2.6 |
| MPZL2 | Myelin protein zero-like 2, TV2 | NM_144765.2 | −2.2 | −1.3 | −2.4 |
| CEP55 | Centrosomal protein 55kDa | NM_018131.4 | −2.2 | −2.0 | −2.1 |
| CXCL1 | Chemokine (C-X-C motif) ligand 1 | NM_001511.3 | −2.2 | −2.5 | −2.8 |
| CCNB2 | Cyclin B2 | NM_004701.3 | −2.2 | −2.2 | −2.3 |
| KIF20A | Kinesin family member 20A | NM_005733.2 | −2.2 | −1.9 | −2.5 |
| RAD51AP1 | RAD51 associated protein 1 | NM_006479.4 | −2.2 | −1.6 | −2.2 |
| GINS2 | GINS complex subunit 2 | NM_016095.2 | −2.2 | −1.7 | −2.9 |
| FAM83D | Family with sequence similarity 83, member D | NM_030919.2 | −2.3 | −1.6 | −2.4 |
| KIAA0101 | KIAA0101 | NM_014736.4 | −2.3 | −2.0 | −2.3 |
| DLGAP5 | Discs, large (Drosophila) homolog-associated protein 5 | NM_014750.4 | −2.3 | −2.0 | −2.3 |
| CCNA2 | Cyclin A2 | NM_001237.3 | −2.3 | −2.2 | −2.8 |
| LOC399942 | LOC399943 | XM_934471.1 | −2.3 | −2.4 | −3.4 |
| MPZL2 | Myelin protein zero-like 2, TV1 | NM_005797.3 | −2.3 | −2.7 | −2.2 |
| TOP2A | Topoisomerase II α 170kDa | NM_001067.3 | −2.3 | −2.4 | −2.6 |
| RRM2 | Ribonucleotide reductase M2 | NM_001034.3 | −2.3 | −1.5 | −2.8 |
| FBXO5 | F-box protein 5 | NM_012177.3 | −2.4 | −1.9 | −2.6 |
| CDCA7 | Cell division cycle associated 7 | NM_031942.4 | −2.4 | −1.9 | −2.5 |
| MCM4 | Minichromosome maintenance complex CMPT 4, TV1 | NM_005914.3 | −2.4 | −1.5 | −2.0 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 | NM_002358.3 | −2.4 | −2.3 | −2.1 |
| UHRF1 | Ubiquitin-like with PHD and ring finger domains 1 | NM_001048201.1 | −2.5 | −1.6 | −2.6 |
| ANGPTL4 | Angiopoietin-like 4 | NM_139314.1 | −2.8 | −2.8 | −2.9 |
| RGS4 | Regulator of G-protein signaling 4 | NM_005613.5 | −3.0 | −3.8 | −3.8 |
| IL1RL1 | Interleukin 1 receptor-like 1 | NM_003856.2 | −3.2 | 3.4 | −5.2 |
HDMVEC, human dermal microvascular endothelial cells; HCAEC, human coronary artery endothelial cells.