Reconstruction of cortical axonal arbors of individual dura-sensitive VPM (A) and Po (B, C) neurons. Numbers in red indicate the coronal plane (millimeters from bregma). The levels of the different coronal drawings are indicated as red lines in the sagittal drawing of the brain. Note that VPM neurons project mainly to S1, S2, and the insula, whereas Po neurons project to multiple cortical areas outside the so-called pain matrix. Au1, Primary auditory cortex; AuD, secondary auditory cortex, dorsal; AuV, secondary auditory cortex, ventral; Br, bregma; cc, corpus callosum; DI, dysgranular insular cortex; Ect, ectorhinal cortex; GI, granular insular cortex; M1, primary motor cortex; PtA, parietal association cortex; PRh, perirhinal cortex; RSA, retrosplenial cortex; RSGb, retrosplenial granular cortex, b region; S1, primary somatosensory cortex; S1BF, primary somatosensory cortex, barrel field; S1DZ, primary somatosensory cortex, dysgranular; S1FL, primary somatosensory cortex, forelimb; S1HL, primary somatosensory cortex, hindlimb; S1Tr, primary somatosensory cortex, trunk area; S2, secondary somatosensory cortex; V2L, secondary visual cortex, lateral area; V2ML, secondary visual cortex, mediolateral.